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KMID : 0370220140580020125
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Yakhak Hoeji
2014 Volume.58 No. 2 p.125 ~ p.128
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Development of Alternative Assay Method without Hazardous Reagent, Chloroform for Urazamide Tablets in Korean Pharmaceutical Codex
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Lee Yoo-Rim
Kim Hyun-Ji
Seo Na-Rae
Kim Kyeong-Ho
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Abstract
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We developed an alternative assay method without hazardous reagent of chloroform for urazamide tablets in Korean Pharmaceutical Codex. The HPLC analytical method was validated by system suitability, linearity, precision, accuracy and robustness. The linearity of the calibration curves in the desired concentration range is good (r2 수식 이미지 >0.999). Precision was obtained less than RSD 1.17%. Accuracy was obtained with recoveries in range of 98.12% and 99.47%. The developed assay could be expected to become valuable tools for revising the Korean Pharmaceutical Codex.
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KEYWORD
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KPC, hazardous reagents, alternative methods, validation, HPLC
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